Bioplant HTR is a patented nonresorbable co-polymer derived from a proprietary process combining polymethylmethacrylate ("PMMA") and polyhydroxyethylmethacrylate ("PHEMA"). Additionally, it contains very thin layers of barium sulfate (for radiopacity) and calcium hydroxide/carbonate which is the direct interface with bone. Since this polymerization reaction occurs in the production laboratory, there is no heat generated in the tissues, and no chance of monomer contamination. While part of Bioplant HTR’s composition is PMMA (acrylic), it should not be confused with the traditional properties and implant experience associated with pure acrylic materials. The synergy of Bioplant HTR’s components results in a unique combination of physical properties not previously seen in any one bone substitute material (porosity, hydrophilicity, negative surface charge, user-friendly and strength). This combination gives the material its unique and beneficial characteristics which make it osteopromotive (i.e., promotes bone and tissue growth). Bioplant HTR has medically important properties making it superior to other bone substitutes available. Bioplant HTR is: Biologically Compatible Osteopromotive Radiopaque Easy to handle Negative surface charge Microporous Hypo-allergenic Graftable surface Strong Hydrophilic Does not support growth of oral pathogens Unlike other synthetic bone substitutes composed primarily of hydroxylapatite, Bioplant HTR is highly porous and strong, easy to handle and apply, graftable and has been proven in clinical studies and tests to be osteopromotive. Bioplant HTR is unique in that it allows surrounding bone and soft tissue to grow into and integrate with the Bioplant HTR. This unique characteristic of Bioplant HTR promotes new bone growth. No competitive bone substitute product promotes bone growth. Bioplant HTR is also the only synthetic bone material that has a graftable and negatively charged surface. Bioplant HTR has properties superior to those of any other bone substitute currently available. It is biologically compatible, strong and not brittle. The hydrophilic nature of Bioplant HTR causes uptake of the blood at the site of use, thereby enhancing clot formation and tissue repair. This property allows easy packing of the site. Bioplant HTR stays where it is applied and will not migrate. Bioplant HTR is microporous which allows biological fixation and adds strength. Greater porosity permits more extensive ingrowth by increased surface area and greater inter-locking fit between the synthetic and bone. Bioplant HTR can be used to prevent the loss of jawbone after tooth extraction ("Ridge Preservation"), to augment the jawbone in preparation of installation of prostheses ("Ridge Augmentation"), to provide foundation for dental implants ("Implant Therapy"), and to replace bone lost to periodontal or gum disease ("Periodontal Defects").